Molecular Imaging for Bio-medical Research with Mice
Home // Medical // Research
File Size: 397.03 KB
Category: Medical & Research
Source: www.jlab.org, Author: stewartm
Bio-medical Research with Mice. Diabetes study: (top) biodistribu- tion of iodine-125 labeled insulin binding in a live mouse, (middle) image co-regis-
Share this info:
Content Inside:
Molecular Imaging for Bio-medical Research with Mice
Molecular Imaging
Researchers at the Department of Energy’s Thomas Jefferson National Accelerator Facility (Jefferson Lab) are collaborating with the College of William and Mary on the implementation of a detector system ideally suited for biomedical research with live small animals. A detector system developed by the collaboration is being used and optimized for detection of the emission of iodine-125. Iodine-125 is the isotope that can be used with certain molecular biology techniques to probe for certain gene products in a live animal. The ability to image gene expression in live animals provides a valuable tool for molecular biology and disease research. cal assistance from Jefferson Lab, has incorporated xray imaging with the iodine-125 imaging system. The x-ray images provide anatomical information to aid in the localization of the iodine-125 labeled molecules. The system is now being used to aid diabetes research in the William and Mary Biology Department. Modifications to this system are underway to permit three-dimensional imaging of the labeled molecules in a live mouse by applying a medical imaging technique called Single Photon Emission Computer Tomography.
Diabetes study: (top) biodistribution of iodine-125 labeled insulin binding in a live mouse, (middle) image co-registration of insulin binding with a digital x-ray radiograph of the mouse, (bottom) digital x-ray radiograph of mouse under study.
Advantages
Current gene expression techniques take snapshots of the state of expression of the gene of interest. In order to get an actual measurement of the animal’s state of expression of the gene of interest, for instance in the brain or endocrine system, the animal’s life must be terminated. The technology developed by the collaboration offers neural scientists and endocrinologists the opportunity to understand processes in real-time and Distribution of a over an extended period of cocaine-like compound time allowing for more complete (RTI-55) in a live study of the genetic processes.
mouse.
Partners
Research was done in collaboration with the Department of Biology at the College of William and Mary which obtained grants from NSF and the ADA; and with the support of the Department of Energy’s Division of Nuclear Physics.
Iodine-125 is unique since commercially available gene probes already exist for this isotope. The iodinelabeled probe attaches to the gene marker of interest and the gamma and x-rays emitted from the isotope decay process are used to image the gene product to millimeter resolution.
Nuclear Physics Spin-off
This medical application spin-off came from research conducted by physicists at Jefferson Lab to develop new high energy particle detector components. These components are called crystal scintillators and position sensitive photo multiplier tubes. This project began in 1996 and is ongoing.
Current Status
The College of William and Mary, with funding from the American Diabetes Association (ADA) and techni-
Comments
Related PDF Files
Today Terms
About Drilling machine seminer project, how to cite FASB website, harga sepeda motor honda, metan mt2 indir, Divar reset password, governing system of turbine, how to bypass evo immobiliser, mt2 energy, gambar ford f150, beyond bluetooth instructions, warmingmt2.com, lemon mt2 download, farm information in marathi, DURGGOV, harga lancer evo 9 indonesia, cisco 8485 DVB, BK-600 pair, foto motor drak, MOTOR DERAK, xtreme MT2 homepage, mercyslk200, block diagram of fire alarm system, yamaha mio sion, harga tzr50, PENNGERTIAN CROSS PLATFORM, peugeot 206 cd stacker pin configuration, learn baloon magic tricks in urdu, BK600 manual, Milling machine seminar report, www.limemt2.tk, T%C4%B0GGER MT2, g lens vs T* lens AND sony, harga honda jazz, matrix mt2 registration, jual audi a4 2002, block diagram of burglar alarm circuit, hargashockbreakermotorhondasuprafit, installing Parallels ToolsFedora 13, Ogilvy on Advertising torrent, sepering tes, modivikasi moto honda 70, cash mt2, Stiker Honda supra , 13 august 2010 kalnirnay, energy mt2 site, modifikasi supra x 2003, foto-foto motor loadrace, electrical turbine motor water, the narnia cookbook pdf, block diagram of burglar alarm, uh-60 operators manual pdf, mobil lancer 2004 bekas, physiotherapy ppt on polio, Sealux d90 price, NZ drunk driving 2010 statistics, mt2 legacy, Sealux d90, gambar mesin injeksen, harga mobil mazda rx8 tahun tertua, hr activities ppt, wind turbine VHDL ams model, harga mobil Mercedes-Benz SLK, hargamotorscopy, blackberry bold manual email reconciliation, mercy c200 th 2004, algorithms in endocrinology, matrixmt2.net download games, physiotherapy of multiple sclerosis ppt, mt2 dynasty, gambarmegapronew, harga Isuzu panther tahun 1994, Dark Revolution 2 Mt2, w3.schools.com oracle contents, Dark-Revolution2 Mt2, Dark Revolution 2 Mt2, Yearbook of Endocrinology download, allnewmuranoindonesia, lemmon mt2 indir, Pdf environmental projects in marathi, download Microbiology:Principles and Applications, semens analysis ppt, Harga cover body honda supra fit 2004, statistical quality control pdf rapidshare, foto honda megapro, free magic tricks in urdu, vixion harga scen, ckd np blansko oil pump, more...